別名
GAF, HBFG-9, HBGF-9, SYNS3
背景
FGF家族成員具有廣泛的有絲分裂和細(xì)胞存活活性，參與多種生物學(xué)過程，包括胚胎發(fā)育、細(xì)胞生長(zhǎng)、形態(tài)發(fā)生、組織修復(fù)、腫瘤生長(zhǎng)和侵襲。FGF9作為一種分泌因子被分離出來，在培養(yǎng)的膠質(zhì)細(xì)胞中表現(xiàn)出刺激生長(zhǎng)的作用。在神經(jīng)系統(tǒng)中，F(xiàn)GF9主要由神經(jīng)元產(chǎn)生，可能對(duì)神經(jīng)膠質(zhì)細(xì)胞的發(fā)育起重要作用。
FGF-9在體內(nèi)參與細(xì)胞增殖、分化和發(fā)育調(diào)控等過程。它在神經(jīng)系統(tǒng)發(fā)育、血管發(fā)生、骨骼發(fā)育、肌肉和軟骨修復(fù)等方面發(fā)揮重要功能。它還具有促進(jìn)血管新生、創(chuàng)傷愈合和組織再生的能力。
FGF9在性別決定中的作用始于它在雌雄雙性腺中的表達(dá)一旦被SOX9激活，它就負(fù)責(zé)與SOX9形成一個(gè)前饋回路，從而增加這兩個(gè)基因的水平。它形成一個(gè)正反饋回路，上調(diào)SOX9，同時(shí)使雌性Wnt4信號(hào)通路失活。
1. Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700.
2. Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996 Jun 21;271(25):15292-7.
3. Wu XL, Gu MM, Huang L, Liu XS, Zhang HX, Ding XY, Xu JQ, Cui B, Wang L, Lu SY, Chen XY, Zhang HG, Huang W, Yuan WT, Yang JM, Gu Q, Fei J, Chen Z, Yuan ZM, Wang ZG. Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet. 2009 Jul;85(1):53-63.
4. Plotnikov AN, Eliseenkova AV, Ibrahimi OA, Shriver Z, Sasisekharan R, Lemmon MA, Mohammadi M. Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. J Biol Chem. 2001 Feb 9;276(6):4322-9.
5. Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700.
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