別名
Mechano growth factor (MGF); Somatomedin-C; IGF1; IGF-I; IGF1A; IGFI.
背景
胰島素樣生長因子1,也稱之生長調(diào)節(jié)素C(somatomedin C),是由人類基因IGF1編碼的蛋白質(zhì)。
因為具備不受抑制的胰島樣活力的作用,所以也被稱為酸硫化因子(nonsuppressible insulin-like activity,NSILA)。IGF-1蛋白由一個肽鏈構(gòu)成,包括70個氨基酸殘基和三個分子內(nèi)二硫鍵,分子量為7,649道爾頓,可分泌到細胞外。最初是從血漿中分離,從結(jié)構(gòu)和功能上與胰島素類似,但是具有更高的促生長活性。促進骨源性成骨細胞內(nèi)葡萄糖的轉(zhuǎn)運,在DNA和糖原的合成,甚至攝取,比胰島素效率更高。是IGF1R的配體,并結(jié)合其α亞單位,引發(fā)酪氨酸激酶β亞基上的酪氨酸殘基自磷酸化,激活下游PI3K-AKT/PKB和Ras-MAPK通路。
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