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SDS
人雄激素受體(AR)酶聯(lián)免疫吸附試劑盒
Catalog #: E01A0636
Sample Type: Biological samples

 

Other Names

Human Androgen Receptor ELISA kit

Androgen receptor isoform 2; AIS; AIS; ANDR; Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); Androgen receptor; DHTR; Dihydro Testosterone Receptor; Dihydrotestosterone receptor; HUMARA; HYSP1; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; Spinal and bulbar muscular atrophy; TFM

Research Area

Signal transduction,  Epigenetics and Nuclear Signaling, Cancer

Background

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.