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SDS
豬抗突觸素抗體(SYP Ab)酶聯(lián)免疫吸附試劑盒
Catalog #: E07A2130
Sample Type: Biological samples

 

Other Names

Porcine Anti synaptophysin antibody ELISA kit

SYP Ab; Major synaptic vesicle protein p38; anti synaptophysin antibody

Research Area

Neuroscience

Background

The protein is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for neuroendocrine tumors;  and its ubiquity at the synapse has led to the use of synaptophysin immunostaining for quantification of synapses.The exact function of the protein is unknown;  it interacts with the essential synaptic vesicle protein synaptobrevin;  but when the synaptophysin gene is experimentally inactivated in animals;  they still develop and function normally.[8] Recent research has shown;  however;  that elimination of synaptophysin in mice creates behavioral changes such as increased exploratory behavior;  impaired object novelty recognition;  and reduced spatial learning.